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November 1, 2025Ecotoxicology and Environmental SafetyOpen Access

Multi-dimensional insights into the association between PFOA exposure and NAFLD: An integrative analysis of epidemiology, transcriptomics, and molecular docking

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Authors

YHYanggang HongLCLI Chun-qiaoYWYi Wang

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Overview

Analysis shows increased risk of NAFLD with higher PFOA exposure, suggesting lipid metabolism disruption and inflammation may play roles.

Key Points

  • To explore the association between PFOA exposure and NAFLD using an integrative analytical approach.
  • Integrated data from NHANES 2003-2012 cohort and global disease burden data.
  • Conducted weighted logistic regression for risk assessment.
  • Performed transcriptomic analysis to identify hub genes related to NAFLD.
  • Utilized molecular docking to assess interactions with hepatic proteins.
  • Higher tertiles of PFOA exposure linked to increased NAFLD risk (adjusted OR = 1.45).
  • Supported nonlinear dose-response relationship through restricted cubic spline analysis.
  • Identified five hub genes involved in lipid metabolism, inflammation, and cell cycle regulation.

Cite This Study

Hong et al. (2025) studied this question.

synapsesocial.com/papers/69254f7dc0ce034ddc359244https://doi.org/10.1016/j.ecoenv.2025.119408
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