What question did this study set out to answer?

To explore the role of Runx2 in the longevity and function of CD8+ T cells during infections.

November 1, 2025The Journal of ImmunologyOpen Access

Runx2 activity in CD8+ T cells promotes longevity and function during acute and chronic infection 4744

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To explore the role of Runx2 in the longevity and function of CD8+ T cells during infections.
Utilized retroviral overexpression and CRISPR knockout of Runx proteins in T cells.
Performed adoptive transfer of OT-1 or P14 cells with altered Runx expression during infections.
Examined protein expression related to T cell function and survival under distinct conditions.
Runx2 is essential for the longevity of memory CD8+ T cells.
Runx2 perturbation impacts the expression of Runx3 and proteins linked to T cell functionality.
Runx2-deficient T cells show reduced survival and functionality during chronic LCMV infection.

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Findings reveal Runx2 promotes functionality and survival in CD8+ T cells during chronic infection, suggesting important roles in longevity.

Michaels-Foster et al. (2025) studied this question.

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Findings reveal Runx2 promotes functionality and survival in CD8+ T cells during chronic infection, suggesting important roles in longevity.