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Investigate the role of P2RX7 in the establishment of exhausted CD8+ T cell subsets during chronic viral infection.

November 1, 2025The Journal of ImmunologyOpen Access

The eATP receptor P2RX7 promotes the establishment of progenitor exhausted CD8+ T cells and optimal response to checkpoint blockade during chronic viral infection 3251

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Investigate the role of P2RX7 in the establishment of exhausted CD8+ T cell subsets during chronic viral infection.
Examined the establishment of progenitor exhausted CD8+ T cells in response to chronic viral infection.
Conducted meta-analyses of gene expression using scRNAseq and protein assays.
Evaluated metabolic functions of P2RX7-KO CD8+ T cells.
P2RX7-KO mice showed decreased numbers of progenitor exhausted CD8+ T cells.
P2RX7-KO Tprog cells exhibited increased glycolytic function and lower mitochondrial respiration.
P2RX7 is essential for optimal response to anti-PD1 therapy in vivo.

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P2RX7 promotes T cell exhaustion and responsiveness to immunotherapy in chronic viral infection, indicating its potential as a therapeutic target.

Salgado et al. (2025) studied this question.

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P2RX7 promotes T cell exhaustion and responsiveness to immunotherapy in chronic viral infection, indicating its potential as a therapeutic target.