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Investigation of immune cell interactions and spatial distribution in HSV-2 infection.

November 1, 2025The Journal of ImmunologyOpen Access

Spatial Landscape of innate and adaptive immune response in Human Herpes Simplex Virus 2 Infection 4413

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Study reveals distinct immune cell roles in HSV-2 infection, highlighting implications for therapeutic vaccine development.

Investigation of immune cell interactions and spatial distribution in HSV-2 infection.
Applied multiplexed immunophenotyping and single-cell spatial transcriptomics.
Studied immune cells in ulcer-forming and asymptomatic HSV infections.
Analyzed T lymphocyte and innate immune cell spatial relationships.
Identified distinct patterns of innate and adaptive immune cell distribution.
Neutrophils, monocytes, and macrophages infiltrated HSV-infected areas.
T cells were mostly in the dermis, with limited cytolytic function.

Zhu et al. (2025) studied this question.

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