What question did this study set out to answer?

To investigate the role of BCMA in modulating microglia and macrophage function in multiple sclerosis.

November 1, 2025The Journal of ImmunologyOpen Access

B cell maturation antigen impacts microglia and macrophage phenotypes in neuro-autoimmune disease 3920

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Findings show altered microglial and macrophage phenotypes in multiple sclerosis, suggesting cytokines impact immunomodulation.

To investigate the role of BCMA in modulating microglia and macrophage function in multiple sclerosis.
Examined BCMA expression in microglial cells and Ly6C+ myeloid cells in EAE mouse model.
Compared CD86 expression and iNOS levels between BCMA-/- and BCMA+/+ mice.
Analyzed effects of BCMA on macrophage polarization in lymph nodes.
BCMA expressed high levels on microglia and Ly6C+ myeloid cells in EAE.
BCMA-/- mice showed altered CD86 expression on microglia.
Increased iNOS levels indicated M1 macrophage polarization in BCMA-/- mice.

Kumar et al. (2025) studied this question.

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