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To explore how thymic epithelial cells can be manipulated to modulate T cell selection and reactivity in autoimmune diseases and transplantation.

November 1, 2025The Journal of ImmunologyOpen Access

Manipulating thymic epithelial cells to modulate thymic selection and reactivity of T cells 4106

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To explore how thymic epithelial cells can be manipulated to modulate T cell selection and reactivity in autoimmune diseases and transplantation.
Engrafted donor TEC into MHC-II KO mice for T cell selection studies.
Utilized mixed lymphocyte reaction to assess T cell functionality.
Validated imaging techniques to analyze TEC organization in thymus.
Emergence of functional CD4 T cells in recipient mice post-TEC engraftment.
Demonstration of T cell reactivity based on selecting MHC.
Identification of a novel approach to modify T cell reactivity through TEC manipulation.

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Findings reveal that manipulating thymic epithelial cells enhances T cell reactivity in auto-immune diseases and transplantation.

Goor et al. (2025) studied this question.

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