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This is a In Vitro Study study.

November 1, 2025The Journal of ImmunologyOpen Access

Altered effector differentiation potential of human fetal naïve CD8+ T cells 9149

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This study reveals altered effector differentiation in fetal naïve CD8+ T cells, suggesting implications for infant immunity and vaccines.

Investigate the differentiation potential of human fetal naïve CD8+ T cells compared to adults.
Analyzed transcriptional and functional profiles of naïve CD8+ T cells from fetal and adult sources.
Utilized fetal spleen and cord blood for fetal T cell isolation and adult spleen or peripheral blood for adult T cell isolation.
Conducted T cell receptor stimulation to assess differentiation and proliferation.
Fetal naïve CD8+ T cells show unique transcriptional profiles distinct from adult cells.
Following T cell receptor stimulation, fetal cells exhibit higher proliferation and altered differentiation characteristics.
Fetal cells demonstrate increased expression of IRF4 and distinct levels of Granzyme B.

Wendy Hsuan Wen Hung (2025) studied this question.

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This study reveals altered effector differentiation in fetal naïve CD8+ T cells, suggesting implications for infant immunity and vaccines.