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November 1, 2025The Journal of ImmunologyOpen Access

Multi-cohort single-cell transcriptomic analysis reveals conserved endotypes of lupus 2451

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Authors

EMEvan MaestriHZHong ZhengPKPurvesh Khatri

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Overview

Analysis demonstrates distinct endotypes in lupus patients, highlighting immune cells' role in disease monitoring.

Key Points

  • To identify conserved endotypes of systemic lupus erythematosus (SLE) and improve molecular characterization.
  • Integrated datasets from 254 SLE patients and 134 healthy controls using single-cell transcriptomics.
  • Computed SMS via pseudobulk gene expression to differentiate patients from healthy controls.
  • Employed k-means clustering to classify patients into high and low SMS expression groups.
  • The SMS distinguished SLE patients with an AUROC of 0.91 in adults.
  • Identified endotypes correlated with immune cell types, including reduced naive CD4+ T cells.
  • Anti-CD19 CAR-T therapy adjusted SMS expression across immune cells.

Cite This Study

Maestri et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3599behttps://doi.org/10.1093/jimmun/vkaf283.368
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