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November 1, 2025The Journal of ImmunologyOpen Access

Cellular and molecular heterogeneity of lung resident T memory cells in protective immunity 2819

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Authors

CLChaofan LiACArka Sen ChaudhuriJSJie Sun

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Overview

Analysis reveals that T memory cells show distinct functional heterogeneity, suggesting implications for respiratory infection protection.

Key Points

  • The study aims to understand the heterogeneity and protective activities of lung resident T memory cells during influenza infection.
  • Analyzed lung TRM scRNA-seq data from influenza infected mice.
  • Identified two polyclonal TRM populations: TRM-EFF and TRM-MEM.
  • Examined the effects of antigen dose on TRM heterogeneity.
  • Observed distinct characteristics of TRM-EFF and TRM-MEM populations.
  • Found that lower antigen dose diminished TRM-EFF counts.
  • Demonstrated that TRM-EFF expands faster during reinfection compared to TRM-MEM.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69254f92c0ce034ddc359a11https://doi.org/10.1093/jimmun/vkaf283.700
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