Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial

Key Points

• This analysis aims to explore cognitive changes in older adults undergoing treatment for depression.
• Secondary analysis of the OPTIMUM randomised controlled trial.
• Participants included older adults receiving pharmacotherapy for treatment-resistant depression.
• Cognitive assessments were performed to evaluate changes over time.
• Cognitive changes were observed in older adults after pharmacotherapy.
• The findings indicate both improvements and potential drawbacks in cognitive function.