Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial

Q: What type of study is this?

This is a Human Clinical Trial study (also classified as: RCT).

Hanadi A Oughli; Nicholas J. Ainsworth; Meryl A. Butters; Patrick J. Brown; Marie Anne Gebara; Torie R. Gettinger; Jordan F. Karp; Helen Lavretsky; Emily Lenard; J Philip Miller; Benoit H Mulsant; Ginger E. Nicol; Charles F. Reynolds; Michael D. Yingling; Eric J Lenze; - -

doi:10.1016/j.lanhl.2025.100767

October 1, 2025The Lancet Healthy LongevityOpen Access

Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial

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Key Points

This analysis aims to explore cognitive changes in older adults undergoing treatment for depression.
Secondary analysis of the OPTIMUM randomised controlled trial.
Participants included older adults receiving pharmacotherapy for treatment-resistant depression.
Cognitive assessments were performed to evaluate changes over time.
Cognitive changes were observed in older adults after pharmacotherapy.
The findings indicate both improvements and potential drawbacks in cognitive function.

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Implication

Secondary analysis of a randomised controlled trial reveals cognitive changes in older adults receiving pharmacotherapy for depression, indicating significant implications for treatment.

Abstract

The US National Institute of Mental Health and the Patient-Centered Outcomes Research Institute.

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Cite This Study

Oughli et al. (2025) studied this question.

synapsesocial.com/papers/69254f97c0ce034ddc359d81 https://doi.org/10.1016/j.lanhl.2025.100767

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Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial

Key Points

No abstract yet

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Implication

Abstract

Discussion

Cite This Study

Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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