Why the study?
Do antidepressants improve depression in elderly patients compared to placebo?
Population
1,326 older patients with depression from 17 randomised, placebo-controlled trials
Comparison
Antidepressant medication vs Placebo
Design
Meta-analysis, randomised, placebo controlled
Authors
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Supports antidepressant use in elderly depression; confirms efficacy of TCAs, SSRIs, and MAOIs in Level 1 meta-analysis.
Do antidepressants improve depression in elderly patients compared to placebo?
TCAs, SSRIs, and MAOIs are effective in treating depression in older patients, though evidence for low-dose TCAs is lacking.
Wilson et al. (2001) studied this question.
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