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December 1, 1997International Journal of Geriatric Psychiatry

Treatment of depression in the elderly: effect of physical illness on response

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Why the study?

Does fluoxetine improve depression response rates in acute geriatric medical inpatients with physical illness?

Population

Acute geriatric medical inpatients with depression and physical illness

Comparison

Fluoxetine for 8 weeks vs Placebo

Design

RCT, randomly assigned, double-blind

Follow-up

8 weeks

Authors

MEMavis EvansMHMargaret HammondKWKen Wilson

Discussion

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Overview

Supports fluoxetine for depression in select physically ill elderly inpatients completing ≥5 weeks; extends subgroup-specific efficacy evidence in geriatric RCTs.

Structured PICO

Does fluoxetine improve depression response rates in acute geriatric medical inpatients with physical illness?

P
Population
Acute geriatric medical inpatients with depression and physical illness
I
Intervention
Fluoxetine for 8 weeks
C
Comparator
Placebo
O
Outcome
Response rate as defined by the 17-item Hamilton Depression Rating Scalepatient reported

Fluoxetine may be effective for treating depression in specific subgroups of physically ill elderly inpatients, particularly those with life-threatening or cerebrovascular diseases.

Cite This Study

Evans et al. (1997) studied this question.

synapsesocial.com/papers/6a704f892fdcb5703edb5910https://doi.org/10.1002/(sici)1099-1166(199712)12:12<1189::aid-gps715>3.0.co;2-z
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Placebo-controlled treatment trial of depression in elderly physically ill patients1997 · 102 citations
  2. 2Depression in the elderly in the community: Effect of physical illness and selected social factors1991 · 27 citations
  3. 3Quantification of physical illness in psychiatric research in the elderly1990 · 87 citations