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August 1, 1997International Journal of Geriatric Psychiatry

Placebo-controlled treatment trial of depression in elderly physically ill patients

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Why the study?

Does fluoxetine improve depression response rates in elderly physically ill inpatients?

Population

82 acute geriatric medical inpatients with depression and physical illness

Comparison

Fluoxetine for 8 weeks vs Placebo

Design

RCT, randomly assigned, double-blind

Follow-up

8 weeks

Authors

MEMavis EvansClatterbridge Cancer Centre NHS Foundation TrustMHMargaret HammondPennsylvania State UniversityKWKenneth WilsonUniversity of Liverpool

Discussion

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Overview

Fluoxetine did not significantly improve depression response rates in elderly physically ill inpatients; leaves open efficacy questions and supports larger trials.

Structured PICO

Does fluoxetine improve depression response rates in elderly physically ill inpatients?

P
Population
82 acute geriatric medical inpatients with depression and physical illness
I
Intervention
Fluoxetine for 8 weeks
C
Comparator
Placebo
O
Outcome
Response rate as defined by the 17-item Hamilton Depression Rating Scalepatient reported

Fluoxetine showed a non-significant trend towards improved depression response rates compared to placebo in elderly physically ill inpatients, though it was well tolerated.

Cite This Study

Evans et al. (1997) studied this question.

synapsesocial.com/papers/6a73daabd0d1650e4d69f52ahttps://doi.org/10.1002/(sici)1099-1166(199708)12:8<817::aid-gps645>3.0.co;2-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A semi-structured clinical interview for the assessment of diagnosis and mental state in the elderly: the Geriatric Mental State Schedule: I. Development and reliability1976 · 706 citations
  2. 2Age, Age of Onset and Course of Primary Depressive Illness in the Elderly *1983 · 42 citations
  3. 3Clinical and cost benefits of liaison psychiatry1981 · 211 citations
  4. 4Psychometric Assessment of Depression in an Elderly General Medical Population Over- or Underassessment?1990 · 49 citations
  5. 5Old Age Mental Disorders in Newcastle upon Tyne1964 · 569 citations