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August 17, 2025Laboratory MedicineOpen Access

Development of trimester-specific reference intervals for thyroid hormones based on real-world data using a maximum likelihood method

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Authors

XCXiaoyan ChenYZYinrui ZouYCYunxia Chu

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Overview

Study reveals trimester-specific reference intervals for TSH and FT4 in pregnancy, indicating effective management of thyroid health.

Key Points

  • To establish trimester-specific reference intervals for TSH and FT4 using real-world data.
  • Analyzed deidentified data for FT4, TSH, and TPO-Ab from medical records between 2014-2019.
  • Used the maximum likelihood method to establish reference intervals in TPO-Ab-negative pregnancies.
  • Included 55,323 records after data cleaning.
  • Established reference intervals for TSH and FT4 for each trimester.
  • TSH reference intervals were narrower than guideline-suggested values.
  • FT4 intervals were comparable to guidelines, with some slight variations in first and second trimesters.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/69254f9ec0ce034ddc35a2a5https://doi.org/10.1093/labmed/lmaf053
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1First-trimester thyroid reference intervals in twin pregnancy: establishment, diagnostic utility, and association with adverse outcomes2025
  2. 2Defining Trimester-Specific Reference Intervals for Thyroid Hormones: Insights from a Bulgarian Monocenter Study2024 · 2 citations
  3. 3Trimester-Specific Reference Range for Thyroid Function Tests (TFTs) in Normal Pregnant Women at a Tertiary Care Centre2025 · 1 citations
  4. 4Global and Indian perspectives on trimester-specific reference intervals for thyroid hormones in pregnant women: a systematic review2026
  5. 5Pregnancy-specific reference intervals for TSH and FT4: novel insights from preconception-gestation longitudinal data2026