Histopathological spectrum of urinary bladder biopsies

Context: Urinary bladder carcinoma is one of the most common malignancies worldwide, and histopathological examination remains the gold standard for diagnosis and classification. Understanding the spectrum of bladder lesions is essential for accurate diagnosis, treatment planning, and prognosis. Aims: The aim is to study the histopathological spectrum of urinary bladder biopsies. Settings and Design: This was a prospective study conducted at a tertiary care hospital in North India over a period of 1.5 years. Subjects and Methods: The present study was conducted in DMCH, Ludhiana, for 1.5 years from 15 th September 2022 to 14 th March 2024. All urinary bladder biopsies and cystectomy specimens received were included in the study. A total of 26,012 specimens were received, of which 132 were urinary bladder biopsies. Statistical Analysis Used: Data were described in terms of range, mean ± standard deviation (±SD), frequencies (number of cases) and relative frequencies (percentages). Results: Of the 132 cases, 85.6% were neoplastic lesions followed by 14.4% non-neoplastic lesions. Amongst the neoplastic lesions, the most common lesion was non-invasive urothelial carcinoma followed by infiltrating urothelial carcinoma. Of the non-invasive urothelial lesions, the most common was non-invasive papillary urothelial carcinoma, low grade. The mean age of the patients was 61.3 years. Conclusions: The most common neoplastic lesion was non-invasive urothelial carcinoma.