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January 1, 2025BioMed Research InternationalOpen Access

In Vivo Wound Healing and Antimicrobial Activities of the Hydroalcoholic Extract and Solvent Fractions of Arisaema schimperianum Schott. (Araceae) Tuber in Mice

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Authors

BABetelhem AwokeDBDaniel BisratBGBetelhem Gebreamlak

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Overview

In vivo evaluation revealed enhanced wound healing and significant antibacterial activities of Arisaema schimperianum extracts, suggesting traditional uses may be validated scientifically.

Key Points

  • This study aimed to evaluate the wound healing and antimicrobial activities of Arisaema schimperianum extracts.
  • Tested 80% methanol extract and solvent fractions in mice using excision and incision wound models.
  • Measured wound contraction, epithelialization period, tensile strength, and hydroxyproline content.
  • Assessed antibacterial and antifungal activities in vitro using the broth dilution method.
  • Formulated ointments at 5% and 10% concentrations for efficacy testing.
  • Both extract concentrations significantly improved wound contraction and tensile strength compared to controls (p < 0.001).
  • The aqueous fraction exhibited the most potent wound healing effects.
  • Histopathological analysis corroborated wound healing improvements.
  • The aqueous fraction inhibited growth of all bacterial strains tested, showing stronger activity against Gram-positive bacteria.

Cite This Study

Awoke et al. (2025) studied this question.

synapsesocial.com/papers/6925572cc0ce034ddc35a687https://doi.org/10.1155/bmri/6699549
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