Retrospective analysis shows rapid decline in serum prolactin in 90% of patients after transsphenoidal surgery, indicating effective surgical decompression.
The postoperative resolution of hyperprolactinemia caused by stalk compression was possible in 90% within a year. The decline in serum prolactin levels typically began within the first 72 hours after surgery, indicating that the hormonal response to surgical decompression is very prompt and effective.
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Oh et al. (2025) studied this question.
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