What question did this study set out to answer?

To evaluate long-term remission rates, endocrine function, and pregnancy outcomes following transsphenoidal prolactinoma resection in patients with galactorrhea-amenorrhea syndrome.

March 1, 1981Annals of Internal Medicine

Galactorrhea-Amenorrhea Syndrome: Follow-up of Forty-Five Patients After Pituitary Tumor Removal

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HTHenry St. George TuckerLund University

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Implication

Longitudinal cohort study demonstrates that six-month postoperative prolactin levels predict long-term surgical cure in galactorrhea-amenorrhea syndrome, indicating pregnancy should be delayed...

Key Points

To evaluate long-term remission rates, endocrine function, and pregnancy outcomes following transsphenoidal prolactinoma resection in patients with galactorrhea-amenorrhea syndrome.
Followed 45 patients after transsphenoidal prolactinoma removal over a period of 1 to 8 years (mean 3.1 years).
Evaluated cure by tumor grade (I–IV) and tracked serum prolactin at 1 week, 2 months, and 6 months postoperatively.
Assessed pituitary lactotrope function with dynamic stimulation tests using thyrotropin-releasing hormone, metoclopramide, chlorpromazine, and insulin-induced hypoglycemia.
Surgical cure rates decreased with increasing tumor grade: 20 of 27 for grade I, 6 of 10 for grade II, 2 of 5 for grade III, and 0 for grade IV tumors.
Relapses occurred in 6 patients with normal prolactin at 1 week and in 3 patients at 2 months post-surgery, whereas a normal prolactin level at 6 months reliably predicted ultimate cure.
Lactotrope stimulation responses were suppressed for 6 months postoperatively, and 19 uneventful pregnancies occurred across 15 patients with normal gestational prolactin elevations.

Cite This Study

Henry St. George Tucker (1981) studied this question.

synapsesocial.com/papers/6a95c136e9bbfe047c2bee50 https://doi.org/10.7326/0003-4819-94-3-302

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Implication

Longitudinal cohort study demonstrates that six-month postoperative prolactin levels predict long-term surgical cure in galactorrhea-amenorrhea syndrome, indicating pregnancy should be delayed...

Galactorrhea-Amenorrhea Syndrome: Follow-up of Forty-Five Patients After Pituitary Tumor Removal

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Implication

Key Points

Cite This Study

Galactorrhea-Amenorrhea Syndrome: Follow-up of Forty-Five Patients After Pituitary Tumor Removal

Discussion

Member takes

Implication

Key Points

Cite This Study

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