Construction of planar chiral ferrocene diketone derivatives via a cascade Pd-catalyzed asymmetric C–H arylation/α-arylation reaction

Junpeng Liu; Congyu Gao; Jianfeng Hu; Wen-Xiong ZHANG; Yong Yang; Hao Zhang; Junpeng Liu; Congyu Gao; Jianfeng Hu; Wen-Xiong ZHANG; Yong Yang; Hao Zhang

doi:10.1039/d5ob01301a

January 1, 2025Organic & Biomolecular Chemistry

Construction of planar chiral ferrocene diketone derivatives via a cascade Pd-catalyzed asymmetric C–H arylation/α-arylation reaction

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Key Points

Planar chiral ferrocene diketones are efficiently synthesized by a Pd-catalyzed cascade reaction, achieving a high yield.
The synthesis results in an impressive 88% yield and 99% enantioselectivity, showcasing its effectiveness.
This method involves an asymmetric C–H arylation and α-arylation reaction designed for high precision.
The findings highlight the potential for practical applications in chiral compound synthesis, with future work needed to explore scalability.

Implication

Pd-catalyzed cascade shows 88% yield and 99% enantioselectivity for ferrocene diketones, indicating efficient synthesis.

Abstract

A Pd-catalyzed cascade via asymmetric C–H/α-arylation efficiently (88% yield) and enantioselectively (99% ee) synthesizes planar chiral ferrocene diketones.

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/6925572cc0ce034ddc35a724 https://doi.org/10.1039/d5ob01301a

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Construction of planar chiral ferrocene diketone derivatives via a cascade Pd-catalyzed asymmetric C–H arylation/α-arylation reaction

Key Points

Implication

Abstract

Discussion

Cite This Study

Construction of planar chiral ferrocene diketone derivatives via a cascade Pd-catalyzed asymmetric C–H arylation/α-arylation reaction

Key Points

Implication

Abstract

Discussion

Cite This Study

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