Mendelian randomization reveals lipid-lowering and PCSK9 effects on COPD risk, suggesting statins' role beyond cholesterol management.
This study genetically identified causal relationships between serum LDL-C levels, the two coding genes HMGCR and PCSK9, and a reduced risk of COPD. These findings suggest that the protective effect of statins on COPD may occur independently of their lipid-lowering function. Further clinical validation is needed to confirm this hypothesis.
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Jia et al. (2025) studied this question.
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