Observational analysis shows enhanced bone resorption in biomimetic environments, indicating the potential of engineered osteoclast units.
A bone-on-chip model integrating encapsulated osteoclasts within biomimetic mineralized collagen was established to recreate simplified bone resorption units. Osteoclast activity was monitored through non-invasive analysis of resorption compartments.
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Conceição et al. (2025) studied this question.
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