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January 1, 2025Биохимия / Biochemistry

DIFFERENTIAL EXPRESSION OF CIRCULAR RNAs IN THE FRONTAL CORTEX OF RATS UNDER ISCHEMIA-REPERFUSION CONDITIONS

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Key Points

To investigate the expression profile of circular RNAs in the frontal cortex of rats following ischemia-reperfusion.
Used whole-genome RNA sequencing
Applied the transient middle cerebral artery occlusion (tMCAO) model
Analyzed circRNA expression 24 hours after tMCAO
Identified 64 differentially expressed circRNAs
Found fold change greater than 1.5
CircRNAs may serve as biomarkers or therapeutic targets for ischemic stroke

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Implication

Analysis reveals differential expression of circRNAs in frontal cortex post ischemic stroke, suggesting potential biomarkers.

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Cite This Study

I. V. Mozgovoy (2025) studied this question.

synapsesocial.com/papers/6925572cc0ce034ddc35a8f6 https://doi.org/10.7868/s3034529425050025

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