Novel Chlorin With Branched Polyamine and Its Photoinduced Antimicrobial Activity

Multiple antibiotic resistance is one of the major security risks in the field of global health. One of the approaches to solving this problem is antimicrobial photodynamic therapy, but currently used clinical photosensitizers are not sufficiently effective against various pathogens. Polycationic molecular constructs enhance the binding and penetration of photosensitizers into poorly permeable gram-negative bacteria. One of the methods for obtaining such conjugates is the introduction of various polyethylenemines into the photosensitizer molecule. In this work, a branched tetraamine was synthesized and introduced into pyrrole ring A of the natural chlorin molecule. The study assessed the photoinduced toxicity of the new photosensitizer in vitro against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and E. coli bacteria. It was established that the obtained chlorin with a branched polyamine residue had an increased bactericidal effect when irradiated with light compared to its structural precursor.