Microarray analysis shows altered gene expression in peripheral blood lymphocytes of breast cancer patients, suggesting implications for disease understanding.
Breast cancer is number one in terms of indicators of mortality and morbidity in women. In postgenomicera it was revealed that pathology development is linked with specificities of gene expression including transcriptional, posttransctiptional, translational, epigenetical regulation. In research was included biomaterial of 16 patients (8 patients with I/ IIstage luminal A breast cancer and 8 healthy women). Functional enrichment analysis using WebGestalt source and different databases (Gene Ontology, KEGG) showed alterations in expression of genes involved in immunological response, metabolism of carbohydrates, glutathione and nicotinamide, DNA repair, ion transport and intracellular signals transition. Obtained results expand our vision about specificities of blood mononuclears transcriptome during breast cancer on early stage.
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V. I. Minina (2025) studied this question.
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