What does this research mean for the field?

The transcriptomic profile of circulating T lymphocytes is predictive of response to neoadjuvant therapy in early breast cancer patients. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Evaluate the correlation between the transcriptomic profile of circulating T lymphocytes and response to neoadjuvant therapy in early breast cancer.

February 19, 2026Clinical Cancer Research

Abstract PS4-01-16: The transcriptomic profile of circulating T lymphocytes is associated with response to neoadjuvant therapy in patients with early breast cancer

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Authors

BCB. ConteUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”VPViviana PensatoFondazione IRCCS Istituto Neurologico Carlo Besta MMM. MellaiUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”

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Implication

Analyzing the transcriptomic profile of circulating T lymphocytes predicts neoadjuvant therapy outcomes in early breast cancer, suggesting new non-invasive monitoring methods.

Key Points

Evaluate the correlation between the transcriptomic profile of circulating T lymphocytes and response to neoadjuvant therapy in early breast cancer.
Collected baseline circulating T lymphocytes from 95 early breast cancer patients
Conducted bulk RNA extraction and gene expression analysis
Calculated 33 immune signatures with prognostic roles
Employed significant analysis of microarrays to compare T cell polarization between responders and non-responders.
49% of patients achieved a complete pathological response (pCR)
Lower expression of genes related to regulatory T cells and inflammation was found in responders
Non-responders exhibited increased expression of neutrophil activation markers and related chemokines
An IL6-JAK-STAT pathway signature was downregulated in T cells of responders.

Cite This Study

Conte et al. (2026) studied this question.

synapsesocial.com/papers/6996a8d4ecb39a600b3efeed https://doi.org/10.1158/1557-3265.sabcs25-ps4-01-16

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Implication

Analyzing the transcriptomic profile of circulating T lymphocytes predicts neoadjuvant therapy outcomes in early breast cancer, suggesting new non-invasive monitoring methods.

Abstract PS4-01-16: The transcriptomic profile of circulating T lymphocytes is associated with response to neoadjuvant therapy in patients with early breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract PS4-01-16: The transcriptomic profile of circulating T lymphocytes is associated with response to neoadjuvant therapy in patients with early breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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