Variability in promoter-operator structure affects transcriptional activity in Bacillus cereus, suggesting implications for gene regulation.
The promoter-operator region of the Bacillus cereus hlyII gene includes an elongated operator region with mirror symmetry, recognizable with the main specific transcriptional regulator HlyIIR. In addition, regions for the global transcription regulators Fur, OhrR, and ResD, are located in the region of the hlyII gene operator. The latter is a transcriptional regulator of the redox-sensitive ResDE signal transduction pathway. Bacillus cereus sensu lato strains were found with a disturbance in the proximal part of the area recognized by HlyIIR and ResD. The essential role of these regions in the expression of the hlyII gene has been demonstrated. Natural strains of Bacillus cereus with deletions in the proximal region of the HlyIIR operator of the hlyII gene have a significantly reduced expression level of hlyII were identified. Disturbances in HlyIIR operator reduce the expression of hlyII several tens of times. The presence of an intact recognition site for ResD reduces the expression of this gene several times under aerobic conditions. These results allow us to determine the influence of structural variability in the promoteroperator region of Bacillus cereus hlyII genes on its transcriptional activity.
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A. M. Shadrin (2025) studied this question.
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