Copper-catalyzed reactions reveal regioselectivity and stereoselectivity in alkynes with amides, highlighting new alkylated enamides.
A chelate-assisted copper-catalyzed 1,2-alkylamidation of alkynes with aldehydes and amides have been proposed. The generation of high-capacity alkylated enamides exhibits stubborn anti -stereoselectivity and β-regioselectivity.
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Yan et al. (2025) studied this question.
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