Retrospective study found significant drug resistance among gram-negative pathogens in hospitalized AECOPD patients, indicating a need for targeted treatments.
Aim The aim of the study is to evaluate the distribution and drug resistance of infectious pathogens in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods This is a retrospective study of AECOPD patients who underwent pathogen evaluation and drug susceptibility tests. Results A total of 199 hospitalized AECOPD patients were analyzed. Among them, 77.9% had monoinfection, and 22.1% had multiple infections. Two hundred and eighty‐eight strains were isolated, with 61.1% gram‐negative, 3.8% gram‐positive, and 35.0% fungi, while 58 strains were colonized. Common bacteria included Haemophilus parainfluenzae , Acinetobacter baumannii , and Pseudomonas aeruginosa . Staphylococcus aureus and Enterococcus faecalis were the main gram‐positive cocci, and Pseudohyphae were the main fungi. Fifty gram‐negative strains showed drug resistance (19 colonized strains), with high resistance to ceftriaxone in A. baumannii , P. aeruginosa , Klebsiella pneumoniae , and Escherichia coli . Methicillin‐resistant S. aureus was resistant to penicillin but sensitive to other antibiotics. Conclusion The study highlights the distribution of pathogens and the prevalence of drug‐resistant strains among AECOPD patients.
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