New Kinase Inhibitors That Are Selectively Cytotoxic for Tumor Cells

To search for substances selectively acting on tumor cells, phenotypic screening in a coculture of tumor cells with non-tumor cells was used in the work. The compound STOCK7S-36520, selectively cytotoxic in the coculture of breast tumor cells MCF7’ and non-tumor MCF10A, contains structural elements characteristic of kinase inhibitors. Analyzing the compound STOCK7S-36520 and its derivative STOCK7S-47016, it turned out that they are new multikinase inhibitors. The highest inhibition of 84% was shown by compound STOCK7S-47016 against GCK kinase. Of interest is the significant selectivity of action against some of the cell lines studied: the selectivity index of STOCK7S-36520 against the prostate tumor cell line PC3 is 29 times compared to the model line of non-tumor fibroblasts VA13.