Case report describes renal mass with salivary gland tumor characteristics, suggesting potential for metastasis.
Background Pleomorphic adenoma is the most common salivary gland tumor and is notably able to metastasize while displaying a benign‐appearing morphological appearance, greatly resembling that of the primary tumor. Case Report Here, we report a case of a 66‐year‐old male who presented with a 7‐month history of a left upper renal mass. Microscopic examination revealed characteristics typical of pleomorphic adenoma, including chondromyxoid stroma and benign ductal and tubular cells. Consequently, a diagnosis of benign mixed tumor resembling a metastasizing pleomorphic adenoma (MPA) to the kidney was made. Conclusions We report a rare instance of a tumor resembling pleomorphic adenoma with metastasis to the kidney, the 13 th reported case of kidney metastasis in the literature. This case is additionally the 2 nd case with metastases to the kidney and no known primary salivary gland tumor. We believe that this entity is most consistent with the histopathological findings reported in our case, despite the lack of a patient history of primary salivary gland tumor. We subsequently compare patient outcomes across all known cases of benign MPA to the kidney or PA‐like tumors in the kidney with patient outcomes described in a 2015 study that analyzed all cases of MPA in the literature.
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Zhang et al. (2025) studied this question.
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