Cell-derived vesicles extruded from adipose mesenchymal stem cells attenuate intestinal inflammation and augment epithelial regeneration in a colitis model

Min Kyoung Jo; Hyeon jeong Jeon; So Hui Kim; Hye Sun Lee; Seong Eun Kim; Sung Ae Jung; HUI CHONG LAU; Sung Soo Park; Seung-Wook Oh; Chang Mo Moon; Min Kyoung Jo; Hyeon jeong Jeon; So Hui Kim; Hye Sun Lee; Seong Eun Kim; Sung Ae Jung; HUI CHONG LAU; Sung Soo Park; Seung-Wook Oh; Chang Mo Moon

doi:10.1039/d4nr05374e

Key Points

The study aims to explore the role of cell-derived vesicles from adipose stem cells in gastrointestinal health.
Utilized a colitis model to assess the effects of adipose stem cell-derived vesicles.
Evaluated inflammation levels and epithelial regeneration in the intestinal tract.
Extruded vesicles significantly reduced intestinal inflammation.
Promoted epithelial regeneration in the colitis model.

Implication

Research demonstrates that stem cell-derived extracellular vesicles reduce intestinal inflammation in colitis, suggesting new therapeutic avenues.

Abstract

Adipose stem cell-derived vesicles attenuate intestinal inflammation and promote epithelial regeneration by overcoming the limitations of stem cells and extracellular vesicles. The graphical abstract was created in BioRender.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Jo et al. (2025) studied this question.

synapsesocial.com/papers/69255737c0ce034ddc35aeb8 https://doi.org/10.1039/d4nr05374e

View Full Paper

Ask AI

Bookmark

Share

Cell-derived vesicles extruded from adipose mesenchymal stem cells attenuate intestinal inflammation and augment epithelial regeneration in a colitis model

Key Points

Implication

Abstract

Discussion

Cite This Study

Cell-derived vesicles extruded from adipose mesenchymal stem cells attenuate intestinal inflammation and augment epithelial regeneration in a colitis model

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading