What question did this study set out to answer?

To isolate and evaluate the biological activities of 3-O-methylviridicatin from Penicillium polonicum.

January 1, 2025Прикладная биохимия и микробиология / Applied Biochemistry and Microbiology

Biologically Active Quinolinone Alkaloid from Marine Fungus Penicillium polonicum KMM 4719

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Isolation of quinolinone alkaloid from marine fungus shows cardioprotective and antifungal activity against Candida albicans.

To isolate and evaluate the biological activities of 3-O-methylviridicatin from Penicillium polonicum.
Isolated marine fungal strain KMM 4719 from Apostichopus japonicus.
Identified strain using molecular genetic markers including ITS, BenA, and CaM.
Extracted alkaloids from the strain culture using ethyl acetate.
3-O-methylviridicatin demonstrated cardioprotective activity for the first time.
Exhibited urease inhibitory activity with an IC50 of 97.3 μM.
Inhibited growth of Candida albicans by 23.2% at a concentration of 100 μM.

S. S. Starnovskaya (2025) studied this question.

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