In vitro experiments show platelet-rich plasma alters metabolic activity and growth factors in fibroblasts from diabetes patients, suggesting age-related effects.
The study explores in vitro the regenerative potential of platelet-rich plasma (PRP) from patients with type 1 diabetes mellitus: in a series of experiments they add PRP to the culture medium of dermal fibroblasts and evaluate in dynamics the metabolic (including the production of reactive oxygen species), migration and proliferation activity of the cells, and they also determine the growth factors and exosomes levels in PRP and the medium. They reveal a decrease in the proliferative, prooxidant and toxic effects of PRP from patients with diabetes mellitus. They are characterized with a decrease in metabolic activity and cell viability in culture with an increase in the percentage of necrosis, while the migration properties of the cells were not impaired. The presence of diabetes mellitus in a patient is also accompanied by a decrease in the stimulating effect of his PRP on dermal fibroblasts in the secretion of growth factors. These effects were most significant in elderly people with diabetes.
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T. I. Vlasova (2025) studied this question.
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