Prospects for Application of Bacillus amyloliquefaciens in Biocontrol, Metabolic Engineering and Protein Expression (Review)

The article presents the characteristics, composition of metabolites and biotechnological properties of Bacillus amyloliquefaciens including structure, biochemical, ecological, genetic properties, application in plant growing, food industry, medicine, as an alternative to conventional antibiotics. Furthermore, the review addresses environmental applications of B. amyloliquefaciens such as bioprotection in vegetable storage, as plant growth promoters and protectors, and as bioremediation agents. The review aims to understand the characteristics, genetic tools, and metabolic capabilities of B. amyloliquefaciens, highlighting its potential as a base cell for synthetic biology, metabolic engineering, and protein expression. We discuss the role of the bacteria in the production of chemicals, enzymes, and other industrial bioproducts, as well as their applications in medicine, such as combating pathogenic bacteria and promoting gut health. In agriculture, B. amyloliquefaciens has shown potential as a biofertilizer, biocontrol agent with antifungal, antibacterial, insecticidal, antiviral properties, and stress tolerance enhancer for various crops. Despite its many potential applications, B. amyloliquefaciens remains underexplored. The review highlights the need for further research and development of advanced engineering methods and gene editing technologies designed specifically for B. amyloliquefaciens, which will ultimately allow its full potential to be realized in scientific and industrial contexts.