Polymer–Lipid Hybrid Nanosystems: An Emerging Advanced Therapeutic Tool

Polymer–lipid hybrid (PLH) nanoparticles have become an appealing therapeutic delivery system owing to their special properties. These nanoparticles are made with polymer and lipid components and have garnered significant interest across therapeutic applications. The combined properties of the polymers and lipids enable improved drug delivery by enhancing the stability, biocompatibility, and controlled drug release of the nanoparticle. The versatility of this form of drug carrier, including biomimetic and biocompatible features, allows the encapsulation of a wide range of therapeutic agents, including hydrophilic and hydrophobic compounds, proteins, and nucleic acids. These drug carriers can be modified and adapted to target the desired site of action, specific cells, and tissues, while minimizing the possibility of off‐target and adverse effects. Thus, this review provides an in‐depth analysis into PLH nanoparticles as a novel delivery system, their inherent characteristics, the functionalization strategies, and their wide applications, while providing their potential for future possibilities.