Red-Shifted D-Luciferin Analogues and their Bioluminescence Characteristics

Pratchaya Watthaisong; Chadaporn Kantiwiriyawanitch; Watcharapa Jitkaroon; Aisaraphon Phintha; Ittiphat Klayparn; Narin Lawan; Philaiwarong Kamutira; Daisuke Sasaki; Surawit Visitsatthawong; Somchart Maenpuen; Ruchanok Tinikul; Jeerus Sucharitakul; Ryo Nishihara; Kazuki Niwa; Yoshihiro Nakajima; Yoshihiro Ohmiya; Pimchai Chaiyen

doi:10.1039/d5cb00287g

January 1, 2025RSC Chemical BiologyOpen Access

Red-Shifted D-Luciferin Analogues and their Bioluminescence Characteristics

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Key Points

The research aims to synthesize and characterize D-Luciferin analogues for enhanced bioluminescence.
Synthesis of six D-Luciferin analogues including 5’,7’-dimethoxy-D-Luciferin and 7’-methylnaphthol-D-Luciferin.
Characterization of bioluminescence properties of the synthesized analogues.
Successfully synthesized six new D-Luciferin analogues.
Demonstrated the bioluminescence characteristics of the novel compounds.

Implication

Synthesis of D-Luciferin analogues enhances bioluminescence potential in luciferases, suggesting new applications.

Abstract

D-Luciferin (D-LH2) is the most used substrate for beetle luciferases in various bioluminescence applications. Here, we successfully synthesized six D-LH2 analogues including 5’,7’- dimethoxy-D-LH2, and 7’-methylnaphthol-D-LH2 as novel compounds. We...

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Cite This Study

Watthaisong et al. (2025) studied this question.

synapsesocial.com/papers/6925573bc0ce034ddc35b088 https://doi.org/10.1039/d5cb00287g

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Red-Shifted D-Luciferin Analogues and their Bioluminescence Characteristics

Key Points

Implication

Abstract

Discussion

Cite This Study

Red-Shifted D-Luciferin Analogues and their Bioluminescence Characteristics

Key Points

Implication

Abstract

Discussion

Cite This Study

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