This approach shows successful synthesis of (1-adamantyl)methyl ketone using sodium hydroxide in acylation reactions with diethylmalonate, indicating efficient carbon chain formation.
Acylation reactions of CH-acids have been studied and an efficient approach to the synthesis of (1-adamantyl)methyl ketone directly from 1-adamantylcarbonyl chlorides has been developed. The proposed method includes successive reactions of carboxylic acid chlorides with diethylmalonate in the presence of sodium hydroxide, further hydrolysis of intermediate ketodiesters in an acidic medium, and decarboxylation.
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Yu.N. Klimochkin (2025) studied this question.
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