Synergistic neurotoxicity of polystyrene nanoplastics and cadmium co-exposure: oxidative stress, mitochondrial dysfunction, and ATF5-mediated mitochondrial unfolded protein response in C. elegans and PC12 cells

Shuyan Niu; Yu Ma; Menghao Guo; Haitao Yang; Liqing Wu; Chenyu Liu; Mengjing Cui; Tianshu Wu; Yuying Xue; Shuyan Niu; Yu Ma; Menghao Guo; Haitao Yang; Liqing Wu; Chenyu Liu; Mengjing Cui; Tianshu Wu; Yuying Xue

doi:10.1039/d5en00909j

January 1, 2025Environmental Science Nano

Synergistic neurotoxicity of polystyrene nanoplastics and cadmium co-exposure: oxidative stress, mitochondrial dysfunction, and ATF5-mediated mitochondrial unfolded protein response in C. elegans and PC12 cells

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Key Points

The aim is to assess the combined neurotoxic effects of polystyrene nanoplastics and cadmium exposure on cellular mechanisms.
Evaluated the effects of polystyrene nanoplastics and cadmium in C. elegans and PC12 cells
Measured oxidative stress and mitochondrial dysfunction
Investigated the role of ATF5 in the mitochondrial unfolded protein response
Induced oxidative stress and mitochondrial dysfunction observed in both C. elegans and PC12 cells
Cadmium exposure exacerbated neurotoxicity caused by polystyrene nanoplastics
ATF5-mediated UPR mt was activated under co-exposure conditions

Implication

This research reveals neurotoxicity from cadmium and oxidative stress in C. elegans and PC12 cells, highlighting combined effects of pollutants.

Abstract

Synergistic neurotoxicity of PS-NPs and Cd co-exposure: oxidative stress, mitochondrial dysfunction, and ATF5-mediated UPR mt in C. elegans and PC12 cells.

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Niu et al. (2025) studied this question.

synapsesocial.com/papers/6925573bc0ce034ddc35b1ed https://doi.org/10.1039/d5en00909j

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Synergistic neurotoxicity of polystyrene nanoplastics and cadmium co-exposure: oxidative stress, mitochondrial dysfunction, and ATF5-mediated mitochondrial unfolded protein response in C. elegans and PC12 cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Synergistic neurotoxicity of polystyrene nanoplastics and cadmium co-exposure: oxidative stress, mitochondrial dysfunction, and ATF5-mediated mitochondrial unfolded protein response in C. elegans and PC12 cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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