Amination modifies trifluoromethylalkenes to synthesize 6-fluoro-1,4-dihydropyrimidines, indicating diverse functional groups can be used.
The chemoselective defluorinative amination of (trifluoromethyl)alkenes with amidines is reported. This transition-metal free method is operationally simple and gram-scalable, tolerates diverse useful functional groups, and gives various attractive 6-fluoro-1,4-dihydropyrimidines in...
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Li et al. (2025) studied this question.
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