Synthesis of 6(pyrrolyl)-azolo[1,5-a]pyrimidine-7-amines by the Clausion–Kaas Method

For the first time, a method for synthesizing pyrrole derivatives based on azolo[1,5-a]pyrimidines using the Clauson–Kaas reaction has been implemented. It was established that among azolo[1,5-a]pyrimidine-6,7-diamines, only the amino group in position 6 enters into selective interaction. The developed approach allows obtaining 6-(pyrrolyl)-azolo[1,5-a]pyrimidine-7-amines with yields of 64–85% and high purity. The direction of the reaction was confirmed by NMR spectroscopy data and X-ray diffraction analysis.