Synthetic study demonstrates 5-amino pyrimidine construction via azirine skeletal remodelling, highlighting strained heterocycles for drug discovery.
a cascade of condensation, intramolecular cyclisation, strain-release-driven azirine ring-opening, and aromatisation. This step-economical strategy highlights the untapped potential of strained azirines as versatile synthons for the synthesis of biologically potent 2,4-arylpyrimidin-5-amines.
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Chaturvedi et al. (2026) studied this question.
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