November 28, 2025PLoS ONEOpen Access

Early upregulation of immune suppressors dominates the macrophage response to Toxoplasma gondii

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Macrophages demonstrate early immune activation upon infection with Toxoplasma gondii, suggesting a pivotal role in infection outcomes.
By 60 minutes, macrophages show increased transcription related to immune activation, highlighting their rapid response to the pathogen.
Utilizing a mouse macrophage-like cell line, time-resolved transcriptomic profiling captured gene expression shifts in real-time during infection.
The findings underscore a complex interaction where Toxoplasma gondii modulates macrophage responses to establish a replicative niche.

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Implication

Analysis reveals immune activation and transcription responses in macrophages infected by Toxoplasma gondii, indicating complex host-parasite interactions.

Cite This Study

Murza et al. (2025) studied this question.

synapsesocial.com/papers/6928f0f9a65b730b9ea79842 https://doi.org/10.1371/journal.pone.0336849

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Implication

Analysis reveals immune activation and transcription responses in macrophages infected by Toxoplasma gondii, indicating complex host-parasite interactions.

Early upregulation of immune suppressors dominates the macrophage response to Toxoplasma gondii

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Discussion

Implication

Cite This Study

Early upregulation of immune suppressors dominates the macrophage response to Toxoplasma gondii

Key Points

Discussion

Implication

Cite This Study

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