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November 28, 2025Angewandte Chemie International Edition

Ionizable Nano‐PROTAC Overcomes Endosomal Entrapment for Enhanced LRG1 Degradation and Tumor Suppression

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Authors

HMHuan MinMSMing Chao SunKHKai-jing Hu

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Implication

Nano‐PROTAC technology degrades LRG1 and induces tumor regression in murine models, suggesting therapeutic promise.

Key Points

  • Enhanced degradation of LRG1 leads to significant tumor regression and apoptosis induction.
  • The novel nano‐PROTAC design integrates a tertiary-amine motif for improved cytosolic delivery and endosomal escape.
  • Analysis focused on 4T1 murine breast tumors reveals effective tumor suppression without systemic toxicity.
  • Highlights a promising strategy to overcome endosomal entrapment in protein degradation therapies.

Cite This Study

Min et al. (2025) studied this question.

synapsesocial.com/papers/6928f106a65b730b9ea79b33https://doi.org/10.1002/anie.202520235
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ionizable Nano‐PROTAC Overcomes Endosomal Entrapment for Enhanced LRG1 Degradation and Tumor Suppression2025 · 10 citations
  2. 2Ionizable Nano‐PROTAC Overcomes Endosomal Entrapment for Enhanced LRG1 Degradation and Tumor Suppression2025
  3. 3Fluorination-Tuned Ionizable Lipids Regulate Nano-PROTAC Trafficking for Enhanced Targeted Protein Degradation2026
  4. 4Pretargeted PROTAC Strategy Enables Precise Tumor Target Degradation via Self-Assembling Peptides2026 · 2 citations
  5. 5Nano-Proteolysis Targeting Chimeras (Nano-PROTACs) in Cancer Therapy2024 · 43 citations