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November 28, 2025Scientific ReportsOpen Access

Synthesis, antiproliferative screening, and molecular docking of some heterocycles derived from N-(1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-hydrazineyl-3-oxoprop-1-en-2-yl)benzamide

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Authors

EEEman A. E. El‐HelwYYYoussef M. YoussefGEGalal A Elsayed

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Overview

Evaluation shows significant cytotoxic activity of heterocycles against breast and colon cancer, suggesting potential as CDK2 inhibitors.

Key Points

  • Compounds demonstrated notable cytotoxic activity against colon cancer (HCT-116) and breast cancer (MCF-7) cell lines, indicating their potential for targeted cancer therapy.
  • Among compounds tested, those 5, 8, 9, and 10 particularly exhibited significant antiproliferative activity, highlighting their relevance in cancer treatment.
  • Molecular docking revealed that compound 9 had the highest binding score of -9.5080 kcal/mol, surpassing that of doxorubicin, indicating strong interaction potential with related proteins.
  • Heterocycles derived from the synthesized hydrazide exhibited selective toxicity, implying enhanced safety profiles for further cancer therapeutic developments.

Cite This Study

El‐Helw et al. (2025) studied this question.

synapsesocial.com/papers/6928f106a65b730b9ea79bafhttps://doi.org/10.1038/s41598-025-27006-9
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