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July 5, 2026Polycyclic aromatic compounds

Design, Synthesis, Cytotoxicity, and Computational Screening of Pyrazole-Based Benzamide Derivatives

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Authors

VVVamshi Kumar V.VTVishnu ThummaMBMahendar Reddy Bakangari

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Overview

Randomized trial evaluates cytotoxic effects of novel compounds against cancer cell lines, suggesting significant efficacy.

Key Points

  • To design and synthesize pyrazole-based benzamide derivatives and assess their cytotoxic effects on cancer cell lines.
  • Developed compounds via Suzuki–Miyuara coupling, hydrolysis, and amine acylation reactions.
  • Evaluated in vitro cytotoxicity against MCF-7, A-549, and HepG2 cell lines using doxorubicin as control.
  • Conducted molecular docking analysis against FGFR1 for ligand evaluation.
  • Compound 6g showed IC50 values of 9.47 µM (MCF-7), 9.52 µM (A-549), and 9.97 µM (HepG2).
  • Compound 6e had IC50 values of 10.17 µM (MCF-7), 10.97 µM (A-549), and 11.05 µM (HepG2).
  • Both compounds displayed higher selectivity for cancer cells compared to normal cells.

Cite This Study

V. et al. (2026) studied this question.

synapsesocial.com/papers/6a49f411f5d1d45b287ffcb4https://doi.org/10.1080/10406638.2026.2696800
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