Multidisciplinary approach improves outcomes in pediatric melanoma, highlighting immunotherapy's limited role and diagnostic challenges.
MM arising within CGMN poses diagnostic and therapeutic challenges. While molecular and epigenomic profiling supports accurate classification and understanding of disease biology, the role of immunotherapy remains uncertain-marked by reduced efficacy and significant immune-related toxicity. A multidisciplinary approach is essential to guide management and improve outcomes in this rare pediatric malignancy.
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Miele et al. (2025) studied this question.
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