Cross-sectional analysis finds elevated IFN-γ and IL-22 correlate with reduced ovarian reserve in women, indicating potential biomarkers for diagnosis.
POI features a unique immunocytokine signature with elevated IFN-γ/IL-22 that correlates with ovarian reserve depletion and shows diagnostic promise. The dissociation between menstrual cyclicity and cytokine patterns implies distinct endocrine-immune pathophysiological mechanisms, positioning these cytokines as potential biomarkers for POI diagnosis and mechanistic research.
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He et al. (2025) studied this question.
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