Clinical trials demonstrate radiosensitization effects through hypoxia interventions, suggesting impactful radiotherapy strategies.
Recent trials employing patient selection based on hypoxia biomarkers have investigated the effects of dose (distribution) modifications, and drug-induced tumor reoxygenation or radiosensitization. Encouraging results from some approaches have laid the foundation for larger follow-up studies that have the potential to change clinical practice. These clinical trials set an important precedent for future trial design and help guide the path for the future of hypoxia-directed radiotherapy.
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Koritzinsky et al. (2025) studied this question.
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