Oxygen-Enhanced MRI Assessment of Radiotherapy-Induced Treatment Effects in Patients with Head and Neck Cancer

Hypoxia is common to most solid tumours and mediates treatment resistance. Oxygen-enhanced (OE)-MRI can identify, map and quantify hypoxia in multiple tumour types including H&N cancer. We build upon previous work to show that OE-MRI biomarkers: (i) can be deployed on multiple MRI systems; (ii) are repeatable; (iii) can detect cohort level response to radiotherapy; (iv) can identify which individual lesions have significant changes in their oxygenation, hypoxic volume and hypoxic fraction.