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November 28, 2025International Journal of Rheumatic Diseases

Genome‐Wide Association Analysis and Multi‐Omic Mendelian Randomization Insight Into the Molecular Network of Immune‐Related Dysfunction in the Pathogenesis of Rheumatoid Arthritis

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Authors

XSXiaohong SongSLShanshan LvLDLin Du

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Overview

Genome-wide association analysis reveals key immune genes in rheumatoid arthritis, suggesting new therapeutic targets.

Key Points

  • Causal genes identified include ERAP2, SWAP70, and LTBR, highlighting their roles in rheumatoid arthritis risk.
  • Single-cell RNA sequencing uncovered dendritic cells' specific contributions to immune response, shaping RA pathogenesis.
  • Genome-wide association analysis across RA cohorts pinpointed significant loci, advancing the understanding of RA genetics.
  • Integrated multi-omics approaches strengthen the case for targeting immune regulatory genes to manage rheumatoid arthritis.

Cite This Study

Song et al. (2025) studied this question.

synapsesocial.com/papers/6928f11ba65b730b9ea7a077https://doi.org/10.1111/1756-185x.70479
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetically supported causal genes for rheumatoid arthritis: Mendelian randomization and co‐localization analyses2024 · 2 citations
  2. 2Decoding rheumatoid arthritis: Biomarker identification and immune profiling via bioinformatics and Mendelian randomization2025 · 1 citations
  3. 3Multi-omics data reveal causal associations of cellular senescence-related genes in rheumatoid arthritis: A summary-data-based Mendelian randomization and co-localization analysis2026
  4. 4Mendelian randomization identifies multiple immune cell surface markers as potential causal contributors and drug targets in rheumatoid arthritis2026
  5. 5Multi‐modal integration of protein interactomes with genomic and molecular data discovers distinct RA endotypes2026